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Frequency of Refractory Hypertension in Turkish Patients and Evaluation of the Factors Affecting Refractory Hypertension

Received: 15 December 2020    Accepted: 15 January 2021    Published: 22 January 2021
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Abstract

Background: This study aimed to determine the frequency of refractory hypertension (RH) and investigate the factors affecting RH in Turkish hypertensive patients. Materials and methods: Totally 400 hypertensive patients (114 males and 286 females) were enrolled. Blood pressure (BP) was measured by patients at home two times a day. The patients were called for controlling in every four weeks, and those who had BP <140/90 mmHg were not followed-up. In patients with BP >140/90 mmHg drug doses were increased or another antihypertensive drug was added and the patients were continued to be followed-up. The total follow-up period was 36 weeks. Patients with persisting BP >140/90 mmHg despite triple medication administration including a diuretic form at least for 3 months at adequate doses were considered to have RH. Results: A total of 63 patients (15.8%), including 14 males and 49 females, were considered to have RH. Body Mass Index (BMI) values of patients with and without RH were 32.16±3.56 and 29.71±3.42, respectively (t=2.92; p=0.005). The rate of obese and morbidly obese patients was higher in the RH group (p<0.005). Duration of hypertension was longer in the RH group (9.7±5.6 vs 7.0±5.7 years, p<0.001). Conclusion: We found the frequency of RH as 15.8%. There’s a significant correlation between BMI and RH. Duration of hypertension increases the prevalence of RH, and should be considered one of the risks for RH.

Published in American Journal of Internal Medicine (Volume 9, Issue 1)
DOI 10.11648/j.ajim.20210901.14
Page(s) 21-25
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hypertension, Antihypertensive Agents, Blood Pressure

References
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Cite This Article
  • APA Style

    Mustafa Temizel, Ugur Dilek Calap, Murtaza Cit, Mansur Azermir, Yucel Arman. (2021). Frequency of Refractory Hypertension in Turkish Patients and Evaluation of the Factors Affecting Refractory Hypertension. American Journal of Internal Medicine, 9(1), 21-25. https://doi.org/10.11648/j.ajim.20210901.14

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    ACS Style

    Mustafa Temizel; Ugur Dilek Calap; Murtaza Cit; Mansur Azermir; Yucel Arman. Frequency of Refractory Hypertension in Turkish Patients and Evaluation of the Factors Affecting Refractory Hypertension. Am. J. Intern. Med. 2021, 9(1), 21-25. doi: 10.11648/j.ajim.20210901.14

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    AMA Style

    Mustafa Temizel, Ugur Dilek Calap, Murtaza Cit, Mansur Azermir, Yucel Arman. Frequency of Refractory Hypertension in Turkish Patients and Evaluation of the Factors Affecting Refractory Hypertension. Am J Intern Med. 2021;9(1):21-25. doi: 10.11648/j.ajim.20210901.14

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  • @article{10.11648/j.ajim.20210901.14,
      author = {Mustafa Temizel and Ugur Dilek Calap and Murtaza Cit and Mansur Azermir and Yucel Arman},
      title = {Frequency of Refractory Hypertension in Turkish Patients and Evaluation of the Factors Affecting Refractory Hypertension},
      journal = {American Journal of Internal Medicine},
      volume = {9},
      number = {1},
      pages = {21-25},
      doi = {10.11648/j.ajim.20210901.14},
      url = {https://doi.org/10.11648/j.ajim.20210901.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210901.14},
      abstract = {Background: This study aimed to determine the frequency of refractory hypertension (RH) and investigate the factors affecting RH in Turkish hypertensive patients. Materials and methods: Totally 400 hypertensive patients (114 males and 286 females) were enrolled. Blood pressure (BP) was measured by patients at home two times a day. The patients were called for controlling in every four weeks, and those who had BP 140/90 mmHg drug doses were increased or another antihypertensive drug was added and the patients were continued to be followed-up. The total follow-up period was 36 weeks. Patients with persisting BP >140/90 mmHg despite triple medication administration including a diuretic form at least for 3 months at adequate doses were considered to have RH. Results: A total of 63 patients (15.8%), including 14 males and 49 females, were considered to have RH. Body Mass Index (BMI) values of patients with and without RH were 32.16±3.56 and 29.71±3.42, respectively (t=2.92; p=0.005). The rate of obese and morbidly obese patients was higher in the RH group (pConclusion: We found the frequency of RH as 15.8%. There’s a significant correlation between BMI and RH. Duration of hypertension increases the prevalence of RH, and should be considered one of the risks for RH.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Frequency of Refractory Hypertension in Turkish Patients and Evaluation of the Factors Affecting Refractory Hypertension
    AU  - Mustafa Temizel
    AU  - Ugur Dilek Calap
    AU  - Murtaza Cit
    AU  - Mansur Azermir
    AU  - Yucel Arman
    Y1  - 2021/01/22
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajim.20210901.14
    DO  - 10.11648/j.ajim.20210901.14
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 21
    EP  - 25
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20210901.14
    AB  - Background: This study aimed to determine the frequency of refractory hypertension (RH) and investigate the factors affecting RH in Turkish hypertensive patients. Materials and methods: Totally 400 hypertensive patients (114 males and 286 females) were enrolled. Blood pressure (BP) was measured by patients at home two times a day. The patients were called for controlling in every four weeks, and those who had BP 140/90 mmHg drug doses were increased or another antihypertensive drug was added and the patients were continued to be followed-up. The total follow-up period was 36 weeks. Patients with persisting BP >140/90 mmHg despite triple medication administration including a diuretic form at least for 3 months at adequate doses were considered to have RH. Results: A total of 63 patients (15.8%), including 14 males and 49 females, were considered to have RH. Body Mass Index (BMI) values of patients with and without RH were 32.16±3.56 and 29.71±3.42, respectively (t=2.92; p=0.005). The rate of obese and morbidly obese patients was higher in the RH group (pConclusion: We found the frequency of RH as 15.8%. There’s a significant correlation between BMI and RH. Duration of hypertension increases the prevalence of RH, and should be considered one of the risks for RH.
    VL  - 9
    IS  - 1
    ER  - 

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Author Information
  • Medicana International Hospital, Department of Internal Medicine, School of Medicine, Biruni University, Istanbul, Turkey

  • Medicana International Hospital, Department of Internal Medicine, School of Medicine, Biruni University, Istanbul, Turkey

  • Medicana International Hospital, Department of Internal Medicine, School of Medicine, Biruni University, Istanbul, Turkey

  • Medicana International Hospital, Department of Internal Medicine, School of Medicine, Biruni University, Istanbul, Turkey

  • Department of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey

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