Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance

Li Ting; Chen Chan; Liu Yonggang; Yin Yan; Li Pin

doi:doi:10.11648/j.ajim.20210902.17

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Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance

Li Ting, Chen Chan, Liu Yonggang, Yin Yan, Li Pin

Published in American Journal of Internal Medicine (Volume 9, Issue 2)

Received: 20 February 2021 Accepted: 6 March 2021 Published: 26 March 2021

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Abstract

Background: Chronic HBV infection has a continuous effect on blood sugar and blood phospholipid metabolism. Metabolic syndrome (MS) and insulin resistance (IR) are the main risk factor leading to diabetes and cardiovascular disease. At present, the relationship between chronic HBV infection and MS was still controversial. Objective: To explore the correlation between hepatitis B virus (HBV) infection status, level of surface antigen-antibody and phospholipid metabolism, insulin resistance (IR). Methods: A retrospective analysis was performed on the clinical data of 423 patients who underwent hepatitis B markers test in the hospital from January 2017 to June 2019. Among them, there were 95 cases with positive hepatitis B surface antigen (HBsAg) in the HBV infection positive group and 328 cases with negative HBsAg in the HBV infection negative group. The serum phospholipid fatty acid maps and IR related indexes were compared between the two groups. The correlation between the level of HBsAg antibody and phospholipid fatty acid maps, IR related indexes were analyzed by Spearman analysis. Results: The levels of saturated fatty acid (SFA) and u-6/u-3 polyunsaturated fatty acid (PUFA) in the HBV infection positive group were higher than those in the HBV infection negative group, while n-6PUFA, n-3PUFA, PUFA, and PUFA/SFA were all lower than those in HBV infection negative group (P<0.05). The levels of fasting blood glucose (FBG) and insulin resistance index (HOMA-IR) in the HBV infection positive group were higher than those in the HBV infection negative group, while fasting insulin (FINS) and islet sensitivity index (ISI) were lower than those in HBV infection negative group (P<0.05). Spearman correlation analysis showed that HBeAg level was positively correlated with SFA, n-6/n-3 PUFA, FBG and HOMA-IR (r=0.381, 0.369, 0.516, 0.453, P<0.001), while negatively correlated with n-3 PUFA, n-6 PUFA, PUFA, PUFA/SFA, FINS and ISI (r=-0.322, -0.306, -0.467, -0.482, -0.465, -0.356, P<0.001). Conclusion: HBV infection may cause changes in the composition of serum phospholipid fatty acid and IR.

Published in	American Journal of Internal Medicine (Volume 9, Issue 2)
DOI	10.11648/j.ajim.20210902.17
Page(s)	91-95
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hepatitis B Virus, Hepatitis B Surface Antigen, Phospholipid Fatty Acid, Insulin Resistance

References

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APA Style

Li Ting, Chen Chan, Liu Yonggang, Yin Yan, Li Pin. (2021). Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance. American Journal of Internal Medicine, 9(2), 91-95. https://doi.org/10.11648/j.ajim.20210902.17

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ACS Style

Li Ting; Chen Chan; Liu Yonggang; Yin Yan; Li Pin. Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance. Am. J. Intern. Med. 2021, 9(2), 91-95. doi: 10.11648/j.ajim.20210902.17

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AMA Style

Li Ting, Chen Chan, Liu Yonggang, Yin Yan, Li Pin. Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance. Am J Intern Med. 2021;9(2):91-95. doi: 10.11648/j.ajim.20210902.17

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@article{10.11648/j.ajim.20210902.17,
  author = {Li Ting and Chen Chan and Liu Yonggang and Yin Yan and Li Pin},
  title = {Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {2},
  pages = {91-95},
  doi = {10.11648/j.ajim.20210902.17},
  url = {https://doi.org/10.11648/j.ajim.20210902.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210902.17},
  abstract = {Background: Chronic HBV infection has a continuous effect on blood sugar and blood phospholipid metabolism. Metabolic syndrome (MS) and insulin resistance (IR) are the main risk factor leading to diabetes and cardiovascular disease. At present, the relationship between chronic HBV infection and MS was still controversial. Objective: To explore the correlation between hepatitis B virus (HBV) infection status, level of surface antigen-antibody and phospholipid metabolism, insulin resistance (IR). Methods: A retrospective analysis was performed on the clinical data of 423 patients who underwent hepatitis B markers test in the hospital from January 2017 to June 2019. Among them, there were 95 cases with positive hepatitis B surface antigen (HBsAg) in the HBV infection positive group and 328 cases with negative HBsAg in the HBV infection negative group. The serum phospholipid fatty acid maps and IR related indexes were compared between the two groups. The correlation between the level of HBsAg antibody and phospholipid fatty acid maps, IR related indexes were analyzed by Spearman analysis. Results: The levels of saturated fatty acid (SFA) and u-6/u-3 polyunsaturated fatty acid (PUFA) in the HBV infection positive group were higher than those in the HBV infection negative group, while n-6PUFA, n-3PUFA, PUFA, and PUFA/SFA were all lower than those in HBV infection negative group (PPr=0.381, 0.369, 0.516, 0.453, Pr=-0.322, -0.306, -0.467, -0.482, -0.465, -0.356, PConclusion: HBV infection may cause changes in the composition of serum phospholipid fatty acid and IR.},
 year = {2021}
}

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TY  - JOUR
T1  - Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance
AU  - Li Ting
AU  - Chen Chan
AU  - Liu Yonggang
AU  - Yin Yan
AU  - Li Pin
Y1  - 2021/03/26
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210902.17
DO  - 10.11648/j.ajim.20210902.17
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 91
EP  - 95
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210902.17
AB  - Background: Chronic HBV infection has a continuous effect on blood sugar and blood phospholipid metabolism. Metabolic syndrome (MS) and insulin resistance (IR) are the main risk factor leading to diabetes and cardiovascular disease. At present, the relationship between chronic HBV infection and MS was still controversial. Objective: To explore the correlation between hepatitis B virus (HBV) infection status, level of surface antigen-antibody and phospholipid metabolism, insulin resistance (IR). Methods: A retrospective analysis was performed on the clinical data of 423 patients who underwent hepatitis B markers test in the hospital from January 2017 to June 2019. Among them, there were 95 cases with positive hepatitis B surface antigen (HBsAg) in the HBV infection positive group and 328 cases with negative HBsAg in the HBV infection negative group. The serum phospholipid fatty acid maps and IR related indexes were compared between the two groups. The correlation between the level of HBsAg antibody and phospholipid fatty acid maps, IR related indexes were analyzed by Spearman analysis. Results: The levels of saturated fatty acid (SFA) and u-6/u-3 polyunsaturated fatty acid (PUFA) in the HBV infection positive group were higher than those in the HBV infection negative group, while n-6PUFA, n-3PUFA, PUFA, and PUFA/SFA were all lower than those in HBV infection negative group (PPr=0.381, 0.369, 0.516, 0.453, Pr=-0.322, -0.306, -0.467, -0.482, -0.465, -0.356, PConclusion: HBV infection may cause changes in the composition of serum phospholipid fatty acid and IR.
VL  - 9
IS  - 2
ER  -

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Author Information

Li Ting

Digestive Endoscopy Center, First Affiliated Hospital of Jinan University, Guangzhou, China
Chen Chan

Digestive Endoscopy Center, First Affiliated Hospital of Jinan University, Guangzhou, China
Liu Yonggang

Department of Digestive Medicine, First Affiliated Hospital of Jinan University, Guangzhou, China
Yin Yan

Department of Infection, First Affiliated Hospital of Jinan University, Guangzhou, China
Li Pin

Department of Digestive Rheumatology, First Affiliated Hospital of Jinan University, Guangzhou, China

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APA Style

Li Ting, Chen Chan, Liu Yonggang, Yin Yan, Li Pin. (2021). Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance. American Journal of Internal Medicine, 9(2), 91-95. https://doi.org/10.11648/j.ajim.20210902.17

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ACS Style

Li Ting; Chen Chan; Liu Yonggang; Yin Yan; Li Pin. Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance. Am. J. Intern. Med. 2021, 9(2), 91-95. doi: 10.11648/j.ajim.20210902.17

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AMA Style

Li Ting, Chen Chan, Liu Yonggang, Yin Yan, Li Pin. Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance. Am J Intern Med. 2021;9(2):91-95. doi: 10.11648/j.ajim.20210902.17

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@article{10.11648/j.ajim.20210902.17,
  author = {Li Ting and Chen Chan and Liu Yonggang and Yin Yan and Li Pin},
  title = {Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {2},
  pages = {91-95},
  doi = {10.11648/j.ajim.20210902.17},
  url = {https://doi.org/10.11648/j.ajim.20210902.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210902.17},
  abstract = {Background: Chronic HBV infection has a continuous effect on blood sugar and blood phospholipid metabolism. Metabolic syndrome (MS) and insulin resistance (IR) are the main risk factor leading to diabetes and cardiovascular disease. At present, the relationship between chronic HBV infection and MS was still controversial. Objective: To explore the correlation between hepatitis B virus (HBV) infection status, level of surface antigen-antibody and phospholipid metabolism, insulin resistance (IR). Methods: A retrospective analysis was performed on the clinical data of 423 patients who underwent hepatitis B markers test in the hospital from January 2017 to June 2019. Among them, there were 95 cases with positive hepatitis B surface antigen (HBsAg) in the HBV infection positive group and 328 cases with negative HBsAg in the HBV infection negative group. The serum phospholipid fatty acid maps and IR related indexes were compared between the two groups. The correlation between the level of HBsAg antibody and phospholipid fatty acid maps, IR related indexes were analyzed by Spearman analysis. Results: The levels of saturated fatty acid (SFA) and u-6/u-3 polyunsaturated fatty acid (PUFA) in the HBV infection positive group were higher than those in the HBV infection negative group, while n-6PUFA, n-3PUFA, PUFA, and PUFA/SFA were all lower than those in HBV infection negative group (PPr=0.381, 0.369, 0.516, 0.453, Pr=-0.322, -0.306, -0.467, -0.482, -0.465, -0.356, PConclusion: HBV infection may cause changes in the composition of serum phospholipid fatty acid and IR.},
 year = {2021}
}

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TY  - JOUR
T1  - Correlation Between HBV Infection Status, Level of Surface Antigen-antibody and Phospholipid Metabolism, Insulin Resistance
AU  - Li Ting
AU  - Chen Chan
AU  - Liu Yonggang
AU  - Yin Yan
AU  - Li Pin
Y1  - 2021/03/26
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210902.17
DO  - 10.11648/j.ajim.20210902.17
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 91
EP  - 95
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210902.17
AB  - Background: Chronic HBV infection has a continuous effect on blood sugar and blood phospholipid metabolism. Metabolic syndrome (MS) and insulin resistance (IR) are the main risk factor leading to diabetes and cardiovascular disease. At present, the relationship between chronic HBV infection and MS was still controversial. Objective: To explore the correlation between hepatitis B virus (HBV) infection status, level of surface antigen-antibody and phospholipid metabolism, insulin resistance (IR). Methods: A retrospective analysis was performed on the clinical data of 423 patients who underwent hepatitis B markers test in the hospital from January 2017 to June 2019. Among them, there were 95 cases with positive hepatitis B surface antigen (HBsAg) in the HBV infection positive group and 328 cases with negative HBsAg in the HBV infection negative group. The serum phospholipid fatty acid maps and IR related indexes were compared between the two groups. The correlation between the level of HBsAg antibody and phospholipid fatty acid maps, IR related indexes were analyzed by Spearman analysis. Results: The levels of saturated fatty acid (SFA) and u-6/u-3 polyunsaturated fatty acid (PUFA) in the HBV infection positive group were higher than those in the HBV infection negative group, while n-6PUFA, n-3PUFA, PUFA, and PUFA/SFA were all lower than those in HBV infection negative group (PPr=0.381, 0.369, 0.516, 0.453, Pr=-0.322, -0.306, -0.467, -0.482, -0.465, -0.356, PConclusion: HBV infection may cause changes in the composition of serum phospholipid fatty acid and IR.
VL  - 9
IS  - 2
ER  -

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